Prefilled auto-injectors segment anticipated to contribute to the highest growth opportunity due to growing demand for intramuscular drug delivery in the global auto-injectors market

Auto-injectors are pen like devices used to deliver a fixed dose of drug to patients and are intended for self-administration. Auto-injectors are gradually becoming the gold-standard in the treatment of various indications like anaphylaxis, multiple sclerosis, rheumatoid arthritis and others. Most of the auto-injectors are spring loaded, and the procedure is relatively simple. These are specialised instruments that can be used to avoid needle stick injury and reduce needle phobia among patients. In 1990, the first reusable auto-injector, known as Imigran was launched for the treatment of migraine. Auto-injector manufacturers are focussed on user centric design approaches to enhance ease-of-use and overcome the unwillingness associated with self-administration of intramuscular injections.

Auto-Injectors are expected to present vast opportunities to investors due to high demand in biologics development. Overall revenues from the pre-filled syringes segment is expected to grow during the forecast period due to the rising need for targeted and sustained drug delivery. In September 2015, Bayer Healthcare reported the launch of Betaconnect – the only electronic auto-injector for the treatment of relapsing-remitting multiple sclerosis (RRMS). The procedure does not require a visit to hospitals, clinics, etc. and reduces dependency on healthcare professionals, which is why auto-injectors are becoming a choice of therapy for patients suffering from anaphylaxis, multiple sclerosis, rheumatoid arthritis and others. Increasing adoption of auto-injectors due to benefits such as increased safety, accuracy and minimal discomfort is expected to fuel market revenue growth over the forecast period.

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The global auto-injectors market was valued at nearly US$ 1700 Mn in 2016. The market is anticipated to exhibit a CAGR of 15.1% during the forecast period and is projected to be valued at nearly US$ 7,000 Mn by the end of 2026.

Global Auto-Injectors Market Analysis & Forecast, By Indication, 2016–2026

Anaphylaxis segment dominated the global auto-injectors market by indication in terms of revenue in 2015 and the trend is projected to sustain throughout the forecast period. Anaphylaxis segment is the most attractive segment with an attractiveness index of 3.55 over the forecast period. Revenue from the anaphylaxis segment is anticipated to register a CAGR of 15% over 2016–2026, to reach more than US$ 6,000 Mn by 2026. Multiple sclerosis segment is expected to be the second most lucrative segment in the global auto-injectors market by indication, with an attractiveness index of 0.2 during the forecast period. Multiple sclerosis segment accounted for 5.3% value share in 2016 and is projected to account for 5.5% share by 2026 end.

Global trend: Reduction in reliance on healthcare provisions due to auto-injectors

Auto-injectors are economical as they reduce about 95% of primary healthcare costs, as there is no need to attend clinics and hospitals for administration of the injection by healthcare professionals. Auto-injectors provide inexpensive home medication and reduce the time consumed at in-patient and out-patient care units. For patients requiring frequent dose administration on weekly and daily basis, the use of auto-injectors reduces the average cost per injection. In addition, auto-injectors reduce needle-stick injuries. Reduction in dependence on healthcare professionals is boosting the use of auto-injectors and is likely to increase the revenue growth of the market over the forecast period.

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Key players in the global auto-injectors market

Some key players in the global auto-injectors market included in this report are Becton, Dickinson and Company, Sanofi, Pfizer, Inc., Mylan N.V., Novartis AG, Bayer AG, Janssen Global Services, LLC, Antares Pharma, Inc., Amgen Inc. and Eli Lilly and Company. Mylan N.V. is a leader in the global auto-injectors market in terms of revenue share. Mylan holds a market share of about 83.7% in the global auto-injectors market owing to the fact that the blockbuster product “Epipen” is a widely sold auto-injector and has a tremendous contribution to the global auto-injectors market. Becton, Dickinson and Company is one of the leading manufacturers of refillable auto-injectors focussing on manufacturing Physioject that is compatible with several injectable drugs. In terms of revenue, Becton, Dickinson and Company holds about 8.4% of the global auto-injectors market share owing to a rising adoption of Physioject. 

Analyst’s Viewpoint

Reduction in price due to approved generic versions will boost the sales revenue of global auto injector devices over the forecast period

Drop in price of Epipen from US$ 600 to US$ 300

Auto-injectors manufacturers are introducing generic versions in order to reduce the overall cost of the device. In order to better serve anaphylaxis patients with epinephrine at an affordable cost, Mylan N.V. has implemented the decision of introducing the generic version of Epipen at half the price. The initial pack of two was sold at US$ 600 till December 2016 which will be sold at US$ 300 from January 2017. This has increased the affordability of insured as well as non-insured patients to opt for Epipen. This drop in price will increase the penetration of the EpiPen auto-injector, which holds around 90% share of the overall market.

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Improving healthcare infrastructure across several countries and regions, coupled with availability of well-developed manufacturing units, facilitates the growth of medical device businesses. The changing attitude of patients towards treatment of generic diseases has indicated a significant rise in preference for self-administration devices such as auto-injectors. Promoting this notion, auto-injectors continue to gain prominence not just as an alternative route for drug delivery but also as point-of-care devices in homecare settings. Future Market Insights recently published its report on the global market for auto-injectors, which projects that by the end of 2026, more than US$ 6,800 Mn worth of auto-injectors will sold globally. Currently valued at US$ 1,673.7 Mn, the global auto-injectors market is being projected to exhibit an impressive value CAGR of 15.1%. 

In the report, titled “Auto-Injectors Market: Global Industry Analysis and Opportunity Assessment, 2016-2026,” nearly three-fourth of global auto-injector revenues have been estimated to come from the US and Canada. While North America is being observed as the largest market for auto-injectors in the world, auto-injector sales will be relatively high in Western Europe as well. And, majority of auto-injectors are expected to be distributed through online pharmacies. Online pharmacies as a distribution channel will register the fastest revenue growth at 18% CAGR, while retail pharmacies will be procuring one-fourth of global market value by the end of 2026. 

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Impact of Self-Injection Practices & Novel Drug Delivery Systems

The global market for auto-injectors is projected to expand aggressively, and the report draws this forecast from identifying the most direct, impactful factors that drive the demand for auto-injectors. Firstly, the demand for auto-injectors is expected to keep soaring on the account of high adoption of self-injection practices by patients. Doctors, as well, are prompting patients to take up self-administration devices such as auto-injectors in order to fulfil their prescribed medication dosages through invasive yet safe administration routes. 

Along with that, the global demand for auto-injectors is also expected to be driven by growing development of novel drug delivery systems. Manufacturers of medical devices are collaborating with clinical scientists in order to pave way for next-gen tools in drug administration. In the years to come, the global auto-injectors market is anticipated to garner surplus demand, particularly for prefilled auto-injectors. In 2017 and beyond, more than 92% of global auto-injectors revenues will be emanating from sales of prefilled auto-injectors. Fillable auto-injectors, on the other hand, will incur a downtick in terms of global revenue share over the latter half of forecast period. 

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Higher Demand for Auto-Injectors in Treatment of Anaphylaxis

Another factor that is inducing growth in demand for auto-injectors is the prevalence of multiple sclerosis and anaphylaxis. Notable disease monitoring associations from across the globe are predicting that these disorders are less likely to cease their occurrence rate among geriatric populations, which is incidentally boosting the demand for auto-injectors. In 2016, anaphylaxis as a disease indication accounted for an estimated US$ 1,500 Mn of global auto-injector revenues. Through 2026, almost nine out of ten auto-injectors sold globally are likely to be used for treating anaphylaxis. Meanwhile, auto-injectors sold for treatment of multiple sclerosis will register a marginal rise through the forecast period. And, revenues amassed from sales of auto-injectors for rheumatoid arthritis are expected to showcase highest CAGR of 18.3%. 

Parallel to their rising demand, the global supply of auto-injectors is also expected to propel by the end of 2026. Increased development of biologics, their use in production of advanced drug delivery devices, reduction of manufacturing prices, and additional cost-savings conferred by technological advancements, are all collectively bolstering the global production of auto-injectors. The report has profiled leading players in the global auto-injectors market, which include Amgen Inc., Novartis AG, Sanofi, Pfizer, Inc., Becton, Dickson and Company, Mylan NV, Bayer AG, Eli Lily and Company, Janssen Global Services, LLC, and Antares Pharma, Inc. 

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