Enzyme inhibition means interruption or decrease in the enzyme activity. The enzyme inhibitors are substances that abolish or reduce the rate of enzyme action. Though enzymes are essential for life, abnormally high enzyme activity can lead to disease conditions. Hence, manipulation of enzyme catalysis with inhibitors is critical for prevention of infectious diseases, treatment of hypertension, control of inflammatory response, intervention in cell growth and cell cycle and much more. Also, besides acting as therapeutic agents, enzyme inhibitors play important roles in biological and clinical research.
Enzyme Inhibitors Market: Drivers and Restraints
The route of inhibitor administration is dependent on the properties and objective of the experiment to be carried out. Immobilized enzymes are used in industries and have a high value for industrial and medicinal enzyme products. Some of the examples of industrial enzymes are glucoamylase, amylase, pepsin, trypsin, glucose isomerase, cellulase and many others. With the emergence of new inhibitor enzymes in the quest for drug discovery, several new inhibition mechanisms are expected. Recently, several software programs have emerged to visualize custom visual interface to see curve fits in real-time, graph transforms, equations using kinetic data and these data tables are directly generated. The challenge is that most times, basic presumptions do not hold true in enzyme reactions and addition of new factors further complicate the calculation of reactor outcome. The outcomes of computer-based kinetic calculations are less realistic with more chances of variants. Another major challenge in the enzyme inhibitor market is that it is less reproducible and bio-applications are unpredictable because of synergy, the interplay of known and unknown physiological, biological, physical, and molecular factors affecting the reaction kinetics.
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Enzyme Inhibitors Market: Segmentation
On the basis of disease indication, the enzyme inhibitor market can be segmented into:
- Chronic Obstructive Pulmonary Disorders
- Cardiovascular Disease
- Gastrointestinal Disorders
- Arthritis
- Inflammatory Diseases
- Others
On the basis of end use industry, the enzyme inhibitor market can be segmented into:
- Pharmaceutical
- Biotechnology
- Food & Beverage
- Others
The majority of drugs to treat a number of chronic and life-threatening diseases are developed with a mechanism of action directed towards enzyme inhibition. Enzyme specificity and potency are the important factors considered while developing a drug. A high specificity and potency ensure that a drug will have fewer side effects and a strong therapeutic effect. Enzyme inhibitors are used as diagnostic agents to screen various diseases thus propelling the growth of enzyme inhibitor market.
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Enzyme Inhibitors Market: Overview
The emerging therapeutic market for enzyme inhibitors used in human therapeutics is very high. New information is available on biochemistry for enzyme inhibitors and classes of enzyme-inhibiting products with broad current or potential therapeutic applications in large markets. However, more than 90 enzyme inhibitors are currently marketed and double those are under development. A better understanding of the emerging enzyme inhibitors on enzyme mechanism is key. In recent years, use of chemical immobilization has extended to immobilized antibodies or antigens in bio-affinity chromatography. In coming years, it is speculated that immobilization techniques of proteins and enzymes will have a greater impact on point-of-care medical and health business in the enzyme inhibitor market.
Enzyme Inhibitors Market: Region-wise Outlook
On the basis of region, the market is segmented into North America, Eastern Europe, Western Europe, Asia-Pacific excluding Japan, Japan, Latin America and the Middle East and Africa. The market for enzyme inhibitors is expanding with the rising incidence of enzyme-based diseases and increasing research and development activities. In developed countries like the U.S. and Europe, the market growth for enzyme inhibitors is high because of better availability of medical facilities, diagnosis rate for the diseases, infrastructure, awareness and available treatment options. In Asia Pacific region, China, Japan, and India are most potential markets for enzyme inhibitors due to growing population, improvement in medical facilities and economic development.
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Enzyme Inhibitors Market: Key Players
Some of the players in the enzyme inhibitors market are AstraZeneca, Merck and Co. Inc., Novartis AG, Pfizer Inc., Ranbaxy Laboratories Ltd, Roche-Genentech Holding Ltd., and Takeda Pharmaceuticals. Other prominent players are Abbott Laboratories Inc., Bayer AG, and Johnson and Johnson Ltd. Vendors in this market are outsourcing different parts of their research work such as toxicology testing, product characterization testing to various contract research organizations. Also, vendors are increasingly engaged in outsourcing part of their enzyme inhibitor drug manufacturing or the entire manufacturing process to various contract manufacturing organizations. Thus, the increase in outsourcing of drug manufacturing is one of the trends witnessed in the enzyme inhibitors market.
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