The emerging importance of Proteinase K

Proteinase K is broad spectrum and highly specific serine protease produced by the fungus Tritirachium album Limber. Proteinase K is useful in general digestion of protein in biological samples by cleaving peptide bonds adjacent to the carboxylic group of aliphatic and aromatic amino acids. Proteinase K helps to remove the unwanted enzymes which are harmful to activity of DNA & RNA and produce high molecular genomic products. The stability of Proteinase K in SDS and urea and the ability to digest native proteins make it useful for a variety of applications, such as protein fingerprinting, removal of nucleases for protein purification, preparation of chromosomal DNA for pulsed-field gel electrophoresis.

Proteinase K considered in the report include lyophilized powder form and liquid form. The lyophilized powder is easy to store and the integrity of product remain same for a long time. The required stock solution is made by adding distilled water at the time of reactions and it saves the wastage of product.

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 The future comes apace

In terms of revenue, the global Proteinase K market is projected to register a CAGR of 6.1% during the forecast period and is expected to be valued at US$ 33.4 Mn by the end of 2026. Biotechnology companies was the dominant end-user segment in the global Proteinase K market in 2015 and is expected to gain traction due to increasing research and developments, investments and adoption of gene therapies in developing regions. The North America market performed well in the year 2015 and contributed 36.2% of the global sales of Proteinase K. The global Proteinase K market is expected to represent US$ 15.8 Mn in terms of incremental opportunity between 2016 and 2026.

The spike of chronic diseases and alternate DNA purification methods likely to impact market behaviour

Growth of the global Proteinase K market is primarily driven by increasing prevalence of chronic diseases, increasing investment by government in research, rising global demand for gene therapy and increasing consumer awareness. In addition, good product stability and specificity and low production cost and wide application are expected to fuel market growth over the forecast period.

However, good availability of other proteases and introduction of new sophisticated technologies that are available for DNA purification might hinder market growth over the forecast period.

Lyophilized powder form to push the market ahead during the forecast period

Based on product, the market is segmented into lyophilized powder form and liquid form. In terms of revenue share, lyophilized powder segment dominated the global Proteinase K market in 2015 and is expected to dominate throughout the forecast period. This segment will witness relatively higher growth rates in terms of value over the forecast period. 

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Mitochondria to come out as a winner during the projection period

Based on diseases application, the global Proteinase K market is segmented into purification of DNA & RNA, in situ hybridization, mitochondria isolation and enzyme removal. In terms of revenue share, purification of DNA & RNA application segment dominated the global Proteinase K market in 2015 and is expected to dominate throughout the forecast period, registering higher CAGR as compared to other applications. Mitochondria isolation is the second most lucrative segment by application in the global Proteinase K market.

North America to rule the roost

The global Proteinase K market is segmented into seven major regions North America, Latin America, Western Europe, Eastern Europe, APEJ (Asia-Pacific excluding Japan), Japan and the Middle East & Africa (MEA). The region of North America is anticipated to dominate the market. US and Canada will be the front runners as the Proteinase K market in the US is projected to register a CAGR of 7.8% over the forecast period to reach US$ 543.8 Mn by the end of 2026 and the Canada Proteinase K market is projected to witness a CAGR of 6.0% over the forecast period to reach US$ 61.3 Mn by the end of the forecast period. After North America, APEJ and Western Europe are expected to be the fastest growing markets in terms of revenue growth in the global Proteinase K market. Countries such as Germany and France will play a crucial role in this region. The Germany Proteinase K market is projected to exhibit a CAGR of 7.9% over the forecast period to reach US$ 81.8 Mn by 2026 and the France Proteinase K market is projected to register a CAGR of 6.7% over the forecast period to reach US$ 53.9 Mn by the end of the assessed period.

Brand acquisitions are on the cards

The report lists some of the major shareholders of the global Proteinase K market.  Laboratories Pvt. Ltd, Sisco Research, Promega Corporation, Bioline and F. Hoffmann-La Roche AG, Worthington Biochemical Corporation, Thermo Fisher Scientific Inc., Merck KGaA, Qiagen N.V. are some of the top market players.

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